Many of you have likely managed to injure yourselves during training while being on a cycle, and you wondered what to do next. It very much depends on the type and extent of the injury, but in general it is recommended to reduce training intensity and also adjust the cycle by lowering the doses or even discontinuing most of the steroids used in the cycle, except for Testosterone (TST). Why lower the doses or discontinue most of the steroids? Because if the injury limits your training intensity, I see no point in using various combinations of steroids, aside from Testosterone itself. And why keep Testosterone? Because discontinuing all AAS would also not be the best choice — facing a deep drop in androgen activity while simultaneously having zero natural testosterone production, as it has already been suppressed by AAS use, is certainly not a good idea. Let’s look at what a cycle might look like that creates the conditions for maximising the acceleration of healing of the injuries that occurred.
What substances is the cycle made of?
1. Testosterone Enanthate or Cypionate
As I already mentioned, if the injury significantly affects your training intensity, it is reasonable to discontinue all AAS and continue only with the use of Testosterone itself at a dose of 200–300 mg per week.
2. BPC-157
The typical daily dose of BPC-157 ranges from 250 to 500 mcg for 4 to 8 weeks, most often 6 weeks. In the first week, it is usually taken at 750 to 1000 mcg and then the dose is reduced to 500 mcg, and in the final week it is reduced to 250 mcg as a maintenance dose.
The daily dose is usually taken all at once (250 or 500 mcg) or divided into 2 doses at higher amounts (for example, at a daily dose of 1000 mcg, the dose is split into 500 + 500 mcg).
BPC-157 is not recommended to be taken before training because the massive increase in blood flow that it causes is counterproductive for injury recovery. It is similar to doing rehabilitation of an injury while applying a heated pad to the injury. This must not be done due to excessive swelling/blood flow. It also should not be applied shortly after training because it has a strong anti-inflammatory effect, and it would likely be undesirable to disrupt the natural post-training inflammatory processes. Simply put, taking BPC-157 is best done in the morning after waking up and in the evening before going to bed. Not before training and not after training.
3. TB-500
The typical weekly dose of TB-500 ranges from 2 to 8 mg. In the initial phase (weeks 1 to 4) the dose is higher, and then the dose is reduced (weeks 5 to 12).
It is usually used longer than BPC-157, for a duration of 8 to 12 weeks.
I personally prefer daily application of TB-500 just like with BPC-157, but there are also people who apply TB-500 once every three to four days in a high dose (for example 1.5 mg TB-500 once every 3 days).
For TB-500, it does not matter when you apply it — studies have not shown differences in effectiveness whether it is administered by injection before or after food. Likewise regarding time of day — it does not matter whether it is taken in the morning, afternoon or evening.
Let me pause here for a moment so we can explain the purpose for which BPC-157 and TB-500 are used in this cycle. Both of these peptides have interesting and very similar effects. They are often used together with the goal of achieving faster healing after various injuries. Let’s go through some of their similarities:
• Wound healing: both of these substances accelerate wound healing and tissue repair. The difference is that BPC-157 influences the migration of fibroblasts, while TB-500 influences actin, through which it affects cell reproduction and migration. However, research has also shown that TB-500 can increase the speed and migration of fibroblasts and also the migration of immune system cells.
• Growth of blood vessels: both of these substances are strong stimulators of blood vessel growth, which is very important because repairing cells in the injured area requires strong nourishment through blood vessels. The primary driving force of blood vessel growth is the hormone VEGF. BPC-157 and TB-500 directly increase the production of VEGF, with the difference that BPC-157 also increases the number of VEGRF-2 receptors. Essentially, the final effect for both peptides is the same — an increased level of VEGF in injury sites.
• Cardiovascular health: TB-500 has several cardiovascular positive properties. It supports the growth and migration of endothelial cells, reduces inflammation and scarring that lead to heart failure. Scientists are also working with TB-500 in research because it has great potential to support long-term recovery after a heart attack. BPC-157 has not been studied as extensively as TB-500 for cardiovascular health, therefore we know relatively little about it. What we know for certain is that it has antioxidant effects and that it neutralises malondialdehyde (MDA), a strong free radical that is a major problem after a heart attack.
• Gastrointestinal effects: Here, when it comes to positive effects in the gastrointestinal tract, BPC-157 will clearly be better, since it is isolated from human stomach juice. BPC-157 helps with various types of gastrointestinal injuries and is especially useful in treating fistulas, which normally take 2 or more years to heal, and BPC-157 in rats significantly shortened the healing time — by up to 25 times. TB-500 does not have such effects, but it works synergistically with many types of antibiotics, which is a very positive effect because many pathogens are becoming resistant to current antibiotics. Regeneration of the gastrointestinal tract often depends on maintaining an environment free of pathogens, and in this sense TB-500 may be beneficial.
• Repair of the musculoskeletal system: A large number of animal studies have been carried out on both of these peptides, in which very positive effects were shown in the treatment of tendon, ligament, and bone injuries. During the use of BPC-157, levels of bFGF, EFG and VEGF in injured tendons increase significantly — the higher these levels are, the faster wounds will heal. BPC-157 can also increase the number of GH receptors in tendons, which is also a very beneficial effect in the healing process. TB-500 is also a driving force in injuries of the musculoskeletal system, but does not have such targeted effects as BPC-157. On the other hand, increased growth and migration of fibroblasts is an important factor in the repair of all tissues, and TB-500 brings this effect. TB-500 can support blood vessel growth at the damaged tissue site and through them also increases the migration of fibroblasts, which certainly has a positive impact on the healing process of various tissues.
As you can see, they have different effects that ultimately have the same goal, and therefore these two substances are very suitable for being used together with the aim of creating a synergistic effect in the treatment of various injuries in different tissues.
I also want to point out that BPC-157 and TB-500 are never used in one syringe, but always separately each on its own.
4. Growth Hormone
GH in the human body plays a key role in the process of growth, regeneration, cell renewal and metabolism. One of the most important mechanisms through which GH influences regeneration is its close connection with IGF-1, since it directly increases its production. And it is IGF-1 that supports cell division and proliferation, accelerates the healing of damaged structures, increases collagen synthesis, strengthens connective tissues, and significantly suppresses inflammatory processes that prolong healing. GH positively affects the viscoelasticity of tendons, the ability to absorb overload, improves adaptation to strength training, accelerates the remodelling of ligaments, and so on. I think there is nothing more to discuss here.
For regenerative purposes with the aim of speeding up the healing of injuries, it is fully sufficient to take 3, maximum 4 IU daily. Its use is of course always long-term, in months. The daily dose can be divided into 1.5 IU in the morning upon waking on an empty stomach and 1.5 IU in the evening before sleep on an empty stomach.
5. Ezetimibe
Ezetimibe is a drug that lowers cholesterol and works differently from statins. It prevents the absorption of cholesterol in the small intestine, thereby preventing its passage from food into the bloodstream. Its primary effect is to reduce LDL cholesterol. It cannot lower triglycerides and only very slightly improves HDL levels.
In the cycle, the daily dose is set at 10 mg; this is basically for those who care about their health as much as possible. It is not a drug that supports the acceleration of injury healing; it has a different purpose, as already mentioned (cholesterol).
6. HCG
HCG is used throughout the entire cycle at a dose of 250 IU. Most of you greatly underestimate the use of HCG during the cycle because you perceive it, due to lack of knowledge, only as a substance thanks to which you will have children, which frankly sounds very funny. HCG is not, for heaven’s sake, about children, nor does it prevent testicular atrophy. HCG is an analogue of LH, which forces your testicles to produce intratesticular testosterone! This means your testicles will not be in an “off” state in the cycle but will continue producing, thanks to which you will not have such a big problem in the PCT! At the same time, during an AAS cycle, the production of DHEA and pregnenolone decreases, and HCG increases their production! A decrease in pregnenolone leads to worsened mood, reduced resistance to stress, causes anxiety, irritability, disrupts emotional stability, creates weaker memory and mental fatigue – and yes, that is exactly why you so often feel like nothing during the cycle. And what about DHEA? Again, its low level is associated with fatigue, depression, lower motivation, weakened immunity, and so on. And yes, this is also why during the cycle you often feel like a “beaten dog”.
I also mentioned that HCG does not prevent atrophy – of course it does not, because it acts only on Leydig cell receptors, which form about 10% of testicular volume, while the remaining part is made up of Sertoli cell receptors, which respond to FSH – and FSH will also be eliminated to a minimum during the cycle due to AAS use, so atrophy will simply occur. If you wanted to prevent testicular atrophy, you would have to use HMG (LH and FSH) during the cycle, which would stimulate sperm production and keep you fertile long-term during the cycle – and only now can we, “dear children”, talk about babies.
7. Anastrozole
The level of E2 in the cycle must always be monitored. Most of you, and I dare say the vast majority of you, focus during the AAS cycle only on gynecomastia, which is one of the most foolish symptoms you can focus on. Because even with increased E2 levels, you may not have any problem with the formation of gynecomastia; each of us has a different number of receptors in breast tissue, arranged differently and with different sensitivity. Long-term elevated and uncontrolled E2 brings more serious problems than just the possibility of developing gynecomastia, for example:
A. Long-term elevated E2 increases the risk of thrombosis (blood clots)
B. Long-term elevated E2 increases prolactin levels, which results in lowered libido and worse erection
C. Long-term elevated E2 causes mood swings, anxiety, depression
D. Long-term elevated E2 causes increased fat storage in the hip and chest area
E. Long-term elevated E2 in men increases the risk of cancer by more than 30% (prostate), etc. – there are more negatives, I will not list them all
Therefore, throughout the entire cycle it is necessary to control estrogen levels with an aromatase inhibitor; in the cycle you have Anastrozole, but it is also possible to use Exemestane at a dose of 10 mg every day or every other day.
2-month cycle for mild injuries
3-month cycle for moderately severe injuries
4-month cycle for severe injuries
Add comment