What is the difference between them?
Semaglutide and Tirzepatide are already officially approved by the FDA and the EU, while Retatrutide is still under research (currently in phase III clinical trials) and therefore not yet approved.
These substances are used on the black market primarily for weight loss purposes.
They are incretin mimetics ⇒ they mimic natural hormones that are released after eating, such as:
• GLP-1
• GIP
• Glucagon
In practice, this leads to:
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Suppression of appetite
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Slower gastric emptying (food stays in the stomach longer, creating a stronger feeling of fullness)
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Better regulation of blood sugar levels
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Influence on fat metabolism and increased energy expenditure (particularly with Tirzepatide and Retatrutide)
As a result, people eat less, feel full for longer, have more stable blood sugar levels (less “craving attacks”), and experience a higher energy output.
he main difference between these compounds lies in which receptors they act on:
• Semaglutide acts only on GLP-1 receptors.
• Tirzepatide acts on both GLP-1 and GIP receptors, which enhances its weight-loss effects.
• Retatrutide acts on three types of receptors – GLP-1, GIP, and glucagon receptors.
Therefore, it is expected to have the strongest effect on weight reduction.
HALF-LIFE
All three of these compounds have a long half-life, which means they can be administered only once a week – something most users appreciate.
• Semaglutide: 7 days
• Tirzepatide: 5 days
• Retatrutide: 5.5 days
MOST COMMON SIDE EFFECTS
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Gastrointestinal issues ⇒ nausea, vomiting, diarrhoea, bloating, constipation.
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Severe dehydration and electrolyte imbalance (when a person cannot eat or drink due to frequent vomiting).
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Rapid weight loss, including loss of muscle mass (especially in people not using AAS).
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Gallbladder problems (inflammation or gallstones).
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Pancreatitis (rare).
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Increased heart rate (tachycardia) – mainly seen with Retatrutide.
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Nutrient deficiencies (vitamins, minerals, proteins), fatigue, hair loss, and weakened immunity due to reduced food intake.
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Rebound effect – rapid weight regain after discontinuation.
All these side effects occur mainly with unnecessarily high doses or when dose titration is skipped.
Semaglutide shows the fewest side effects, Tirzepatide slightly more, and according to current data, Retatrutide the most.
OZEMPIC FACE / BODY
What is it about?
During rapid weight loss, a person loses not only fat but also muscle mass. (Continued on the next page.)
Excessive fat loss in the facial area makes the face appear saggy, wrinkles become more pronounced, and the person can look several years older.
The same happens in the thighs, buttocks, and arms, where loss of muscle mass causes a person to look unhealthy and aged.
This effect occurs not only with Semaglutide, but also with Tirzepatide and Retatrutide.
HOW TO AVOID IT?
• Lower doses
• Slower rate of weight loss
• Adequate protein intake
• Use in combination with AAS, which helps minimise muscle loss
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